It is the most common disease affecting extensive host range including chickens, turkeys, pheasants, pigeons, waterfowl, sparrows and other free-flying birds.

The causative organism of fowl cholera is Pasteurella multocida. The organism can survive at least one month in droppings, three months in decaying carcasses and two to three months in soil. Pasteurella apparently enters through oral and upper respiratory tract. Body excreta of diseased birds that contaminate soil, water, feed, etc. is the major source of infection.

In the peracute form, symptoms may be absent; in the acute form some birds may die without showing symptoms, but many others are visibly ill before death. Characteristic symptoms include stupor, loss of appetite, rapid weight loss, lameness resulting from joint infection, swollen wattles, difficult breathing, watery yellowish or green diarrhea and cyanosis or darkening of the head and wattles.

Lesions may be lacking in birds dying during peracute outbreaks. When present, lesions may resemble those associated with any acute septicemic bacterial infection, often those of fowl typhoid. Typical lesions may include pinpoint hemorrhages in the mucous and serous membranes and/or abdominal fat; inflammation of the upper third of the small intestine; light, firm "parboiled" appearance of the liver; enlarged and congested spleen.

Although drugs usually alter the course of a fowl cholera outbreak, affected birds remain carriers and the disease has a tendency to recur when treatment is discontinued. This may necessitate prolonged treatment with drugs added to the feed and water. Sulfa drugs and broad spectrum antibiotics (Penicillin) usually control losses.